Neocide@PC-300 preservative

Key Advantages:

  1. Comprehensive Antimicrobial Power:

• Effectively combats bacteria, fungi, and yeast.

  
  

  2. Swift Microbial Elimination:

• Rapidly eradicates microbial activity and prevents resurgence.

  
  

  3. Formaldehyde-Free Assurance:

• Achieves antimicrobial efficacy without formaldehyde, ensuring cost-effectiveness.

  
  

  4. Low-Dose Effectiveness:

• Excels in low concentrations (15~30ppm) with prolonged effectiveness.

  
  

  5. Versatile Formulation Compatibility:

• Harmonizes seamlessly with various surfactants.

  
  

  6. Unparalleled Chemical Stability:

• Shows exceptional stability, compatible with diverse formulations, devoid of metal ions.

  
  

  7. Solvent Harmony:

• Integrates seamlessly without disrupting reactions, enzyme-compatible.

  
  

  8. Preservation of Antibody Binding:

• Safeguards antibody binding, non-interfering with electrodes (excluding chloride).

  
  

  9. Crystal-Clear Composition:

• Colorless, maintaining transparency in reactions.

  
  

  10. Wide pH Resilience:

• Applicable across pH 2~8.5, remains effective at pH ≤ 3.5.

  
  

  11. Extended Shelf Stability:

• Unopened products stable for three+ years.

  
  

  12. Total Water Solubility:

• Fully dissolves, ideal for aqueous formulations in reagent kits.

  
  

  13. Safe Utilization:

• Uses harmless chemicals, ensuring secure disposal.

  
  

  14. Environmental Friendliness:

• Exhibits remarkable biodegradability, leaving no ecological footprint.

  
  

Note: pH remains pivotal, especially in acidic or weak alkaline environments, ensuring unwavering stability.

Chemical Identification

The active ingredients of the Neocide® PC-300 in vitro diagnostic reagent-specific bacteriostatic agent are a mixture of two isothiazolinone derivatives, including 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-Methyl-4-isothiazolin-3-one (MIT), in a ratio of 3:1. 

The product composition also includes stabilizers (alkyl carboxylate stabilizers) and solvents (modified glycol), with the main raw materials sourced from reputable chemical companies.

• Active Ingredient A.I. (Isothiazolinones, CMIT/MIT 3:1) 3.0~3.6(w/w)

• Stabilizer (Alkyl carboxylate) 2.0~3.0% (w/w)

• Solvent Inerts (Modified glycol) 93.4~95.0%

Application

The stability of the Neocide® PC-300 bacteriostatic agent in product applications is mainly influenced by pH. The bacteriostatic agent is more stable in acidic environments (pH<7), but sensitive to temperature in weak alkaline environments (preferably pH<8.5). In such cases, it is generally required to store the final product at temperatures below 25oC. For pH-related research in applicable products, please conduct additional experiments based on the product's characteristics. The following studies will help you understand more application requirements.

• The advantages of Isothiazolinone are broad-spectrum antibacterial and antifungal properties. The disadvantage is that the degradation rate of Isothiazolinone increases with the increase of pH value in the solution (CMIT is not heat-resistant and alkali-resistant, but MIT is heat-resistant and alkali-resistant).

• The compound thiadiazolone is relatively stable at low temperatures, but its degradation rate increases with the increase in solution temperature. At pH 7, it rapidly degrades under natural light (t ½ = 322h). It is recommended to store the raw material and finished product away from light.

• Solutions containing sulfides and iron ions accelerate the photodegradation of isothiazolinone. Divalent ions such as copper, zinc, manganese, magnesium, and phosphate can inhibit the chemical degradation of isothiazolinone