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GB01030
NeoCide
| Part No. | GB01030 | |||
| CAS NO: | 2634-33-5 | |||
| EINECS NO | 2220-120-9 | |||
| Ingredients | Benzisothiazolinone (BIT) | |||
| Content of active ingredients | 9.5-10.0% | |||
| Molecular Formula | C7H5NOS | |||
| Molecular Weight : | 151.18 | |||
| Applicable PH range | 2~12 | |||
| Brand: | Neocide® | |||
| Packaging | Pkg of 400mL/5kg/25kg | |||
| Storage | Room temperature | |||
| Shelf life | 1 year | |||
| Items | Specification | |||
| Apparence | Clear light yellow to yellow liquid | |||
| Colour (APHA) | 60 maximum | |||
| Odour | Conforms to claims | |||
| Active Ingredients | BIT 9.5 – 10.0% (g/100g) (UV/HPLC) | |||
| Density | 1.05~1.08 , 25°C | |||
| Self-PH Value | 11.5-13.0 (10% aqueous), 25°C | |||
| Usage: | ||||
| NeoCide BIT-10 is 10% benzoisothiazolinone in alkaline potassium hydroxide solution using a special process (and contains the synergistic agent phenoxyethanol/octanediol) which is more easily dissolved in the formulation of IVD reagents. The recommended use level 0.1-0.5% (about 1-5L in 1000L reagent). No formaldehyde release and excellent stability in high temperature and alkaline environment. | ||||
Desription:
NeoCide BIT-10 preservative is a colorless or pale yellow transparent liquid, which is an effective bacteriostatic agent for clinical blood cell analysis, biochemical analysis and immunoassay, including various reagents, quality control products, calibration products, diluents, cleaning solutions and buffers. Because the product has a wide range of the effect of inhibiting microbial growth, excellent compatibility and stability, low toxicity and biodegradability.
NeoCide® BIT - 10 bacteriostatic agent as a kind of ideal, can replace sodium azide (drama) inflammable, explosive, thimerosal (including organic mercury) and gentamycin (yi resistance) traditional bacteriostatic agent such as a new type of antibacterial products. The product has a wide range of inhibition of microbial growth, good compatibility and stability, low toxicity and biodegradable, so that the diagnostic reagent has a longer period of validity and bottle opening validity. During the use of the clinical test instrument in the hospital, it is easy to catch bacteria.
Advantage:
NeoCide BIT-10 preservative has become an ideal and effective preservative for in vitro diagnostic reagents due to its broad spectrum activity, excellent compatibility and stability, and low toxicity at the application concentration.
It is compatible with all kinds of emulsifiers, surfactants and other components, and can be dissolved in any alcohol or water. Strong stability, stored at -20℃ to 40℃ for a year without change, the active ingredient can withstand the high temperature of 150℃.Therefore, it has a long-term protection function, and can protect the system from the erosion of bacteria, mold and yeast.
The fungicide is one of the new generation of industrial fungicides rising in the world. In the early 1980s imperial chemical industries invested 5.5 million pounds to develop a continuous process. The study on the synthesis of this fungicide was started in 1982 in China. The original powder of BIT is a solid powder with a melting point of 156℃, a solubility of 0.14% in water at 25℃, and a solubility of 1.5% at 90℃. However, the sodium salt or potassium salt of the product is easily soluble in water. The BIT-10 of crystal albicide is compounded with potassium hydroxide solution, which makes the product more stable. And NeoCide ®PC isothiazolinone series of antibacterial agents to form a synergistic antibacterial effect. Its features and advantages include but are not limited to：
o Broad-spectrum, long-acting kill a variety of bacteria, fungi and yeast, achieve good bacteriostatic effect
o is compatible with various emulsifiers, surfactants and other components, and can be dissolved in alcohol and water
o is stable, with no change at -20°C to 40°C for one year, and the active components are stable at 150°C
o is applicable to a wide range of pH, compatible with various enzymes, and does not inhibit the binding of antibodies
o is low toxicity and does not contain heavy metals or halogen compounds
o is stable to amines o contains no formaldehyde, low odor and no VOC
NeoCide BIT-10 Preservative can replace Sodium Azide (NaN3) which widely applied to in vitro diagnostic reagents.
In most cases (alkaline), Sodium Azide has a good antibacterial effect, but Sodium Azide can inhibit the activities of horseradish peroxidase (HRP), superoxide dismutase and other enzymes, so Sodium Azide cannot be added to the secondary antibody containing horseradish peroxidase.
At the same time, Sodium Azide has the risks of explosion, very sensitive compounds with heavy metals and the risk of toxicity, inhibit cytochrome oxidase and other enzymes, and can block the formation of oxyhemoglobin in the body, leading to death. Due to the inflammable, explosive and highly toxic nature of Sodium Azide as a dangerous chemical, its procurement, storage, use and other links of the state have special regulatory requirements, its use is increasingly limited.
NeoCide BND-10 Preservative can also replace Thimerosal, which was widely applied to in vitro diagnostic reagent, it for both gram positive and negative of strong antibacterial ability, as the broad-spectrum antibacterial agent, because a small amount of organic mercury in theory has the nerve toxicity, so the use of thimerosal security issues by the attention of people
