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GB01005
NeoCide
| Part No. | GB01005 | |||
| CAS NO: | 30007-47-7 | |||
| EINECS NO | 250-001-7 | |||
| Ingredients | 5-Bromo-5-Nitro- 1,3-Dioxane (BND) | |||
| Content of active ingredients | 9.5~10.5% | |||
| Molecular Formula | C4H6BrNO4 | |||
| Molecular Weight : | 212 | |||
| Applicable PH range | 5~8.5 | |||
| Brand: | Neocide® | |||
| Packaging | PKg of 400mL/5L | |||
| Storage | Room temperature and sealed from light | |||
| Shelf life | 2 years | |||
| Items | Specification | |||
| Apparence | Colorless to yellow transparent liquid | |||
| Color | ≤20 Hazen units | |||
| Odour | Conforms to claims | |||
| Assay,W/W,% | 9.5~10.5% (HPLC/GC) | |||
| Density,g/ml 25℃ | 1.06~1.09 | |||
| Refractive index | 1.43~1.45 (25 ℃) | |||
| Usage: | ||||
| NeoCide BND-10 Preservative is 10% 5-Bromo-5-nitro-1,3-dioxane in a modified propylene glycol using a special process to make it easier to dissolve in the formulation of IVD reagents. The recommended use level is 0.1-0.5% (about 1-5L in 1000L). Recommended to use it with other preservatives. Unstable in high temperature (> 40oC) and alkaline environment, easy to turn dark in sunlight. | ||||
Description:
NeoCide BND-10 preservative is designed for controlling microorganisms in biological media for in vitro diagnostic (IVD) products. The product contained 10% of 5- Bromo-5- Nitro-1,3-Dioxane in propylene glycol solution, colorless or light-yellow transparent liquid, with special bromine odor, which is a highly efficient biocide can be used for Hematology analysis, Chemistry analysis and Immunoassay analysis reagent as preservative, which is applied to all kinds of reagents including, controls, calibrators, diluent, system cleaning and buffer etc. Since the product has a wide range of the effect of inhibiting microbial growth, excellent compatibility and stability, low toxicity and biodegradability, NeoCide BND-10 preservative as one of option, can replace Sodium Azide, Thimerosal and Gentamycin. NeoCide BND-10 preservative can inhibit the growth of bacteria, fungi, yeasts in reagents for prolonged periods, thereby increasing a product’s shelf life and open vial stability. The water solubility permits easy incorporation into IVD reagents. Further, it does not affect the functionality of most enzyme- or antibody-linked reactions, and will not interfere with assay indicators, the material absorption peak at about 214 nm.
Key Advantage:
NeoCide BND-10 preservative has broad spectrum activity, excellent compatibility and stability, in the use of concentrations of low toxicity, became the ideal efficient antiseptic in vitro diagnostic (IVD) reagents.
As one of important invention, Bromine related compounds had been developed as antimicrobial agents in the last seventy's, especially Benzalkonium Bromide and Bronopol, these products are both biocide and surfactant with detergent function, as a disinfectant and preservative cosmetics production and extensive use in medical, although bacteriostatic effect is good, but because these compounds in aqueous solution can be precipitated, easy to change color and prone to bubbles, generally cannot be used as preservative in most of the in vitro diagnostic (IVD) reagent.
The formation of 5-bromo-5-nitro-1,3-dioxane (BND) can not only improve the bacteriostatic ability, but also increase the stability under alkaline conditions, reduce discoloration and no longer release formaldehyde. BND-10 which is 10% propylene glycol solution, easily applied into various kinds of in vitro diagnostic reagent, and can work with NeoCide ® PC series Preservatives like Isothiazolinone. Its features and advantages include but are not limited to:
o Against bacteria, fungi and yeast all have better inhibition effect.
o Broad-spectrum and quickly eliminate the activity of microorganism and biofilm.
o Low concentration, low cost, no interference to the color of the reagent.
o Stable, at the same time worked as surfactant
o Suitable for a wide range of pH, compatibility with enzymes and antibodies
o Environment friendly, biodegradability
Clinical Hematology analysis system in the hospital could be contaminated easily as the reagent pickup systems or pipeline direct contact with blood, in the analysis process, which generated biofilm easily. To use BND-10 as antibacterial agent against streptococcus pneumoniae in diluent and cleaning solution has special effect to extend the shelf life and open shelf life stability. In the IA analysis, BND-10 Preservative as one of first choice applied to most of reagents
NeoCide BND-10 Preservative can replace Sodium Azide (NaN3) which widely applied to in vitro diagnostic reagents. In most cases (alkaline), Sodium Azide has a good antibacterial effect, but Sodium Azide can inhibit the activities of horseradish peroxidase (HRP), superoxide dismutase and other enzymes, so Sodium Azide cannot be added to the secondary antibody containing horseradish peroxidase. At the same time, Sodium Azide has the risks of explosion, very sensitive compounds with heavy metals and the risk of toxicity, inhibit cytochrome oxidase and other enzymes, and can block the formation of oxyhemoglobin in the body, leading to death. Due to the inflammable, explosive and highly toxic nature of Sodium Azide as a dangerous chemical, its procurement, storage, use and other links of the state have special regulatory requirements, its use is increasingly limited. NeoCide BND-10 Preservative can also replace Thimerosal, which was widely applied to in vitro diagnostic reagent, it for both gram positive and negative of strong antibacterial ability, as the broad-spectrum antibacterial agent, because a small amount of organic mercury in theory has the nerve toxicity, so the use of thimerosal security issues by the attention of people.
| Part No. | GB01005 | |||
| CAS NO: | 30007-47-7 | |||
| EINECS NO | 250-001-7 | |||
| Ingredients | 5-Bromo-5-Nitro- 1,3-Dioxane (BND) | |||
| Content of active ingredients | 9.5~10.5% | |||
| Molecular Formula | C4H6BrNO4 | |||
| Molecular Weight : | 212 | |||
| Applicable PH range | 5~8.5 | |||
| Brand: | Neocide® | |||
| Packaging | PKg of 400mL/5L | |||
| Storage | Room temperature and sealed from light | |||
| Shelf life | 2 years | |||
| Items | Specification | |||
| Apparence | Colorless to yellow transparent liquid | |||
| Color | ≤20 Hazen units | |||
| Odour | Conforms to claims | |||
| Assay,W/W,% | 9.5~10.5% (HPLC/GC) | |||
| Density,g/ml 25℃ | 1.06~1.09 | |||
| Refractive index | 1.43~1.45 (25 ℃) | |||
| Usage: | ||||
| NeoCide BND-10 Preservative is 10% 5-Bromo-5-nitro-1,3-dioxane in a modified propylene glycol using a special process to make it easier to dissolve in the formulation of IVD reagents. The recommended use level is 0.1-0.5% (about 1-5L in 1000L). Recommended to use it with other preservatives. Unstable in high temperature (> 40oC) and alkaline environment, easy to turn dark in sunlight. | ||||
Description:
NeoCide BND-10 preservative is designed for controlling microorganisms in biological media for in vitro diagnostic (IVD) products. The product contained 10% of 5- Bromo-5- Nitro-1,3-Dioxane in propylene glycol solution, colorless or light-yellow transparent liquid, with special bromine odor, which is a highly efficient biocide can be used for Hematology analysis, Chemistry analysis and Immunoassay analysis reagent as preservative, which is applied to all kinds of reagents including, controls, calibrators, diluent, system cleaning and buffer etc. Since the product has a wide range of the effect of inhibiting microbial growth, excellent compatibility and stability, low toxicity and biodegradability, NeoCide BND-10 preservative as one of option, can replace Sodium Azide, Thimerosal and Gentamycin. NeoCide BND-10 preservative can inhibit the growth of bacteria, fungi, yeasts in reagents for prolonged periods, thereby increasing a product’s shelf life and open vial stability. The water solubility permits easy incorporation into IVD reagents. Further, it does not affect the functionality of most enzyme- or antibody-linked reactions, and will not interfere with assay indicators, the material absorption peak at about 214 nm.
Key Advantage:
NeoCide BND-10 preservative has broad spectrum activity, excellent compatibility and stability, in the use of concentrations of low toxicity, became the ideal efficient antiseptic in vitro diagnostic (IVD) reagents.
As one of important invention, Bromine related compounds had been developed as antimicrobial agents in the last seventy's, especially Benzalkonium Bromide and Bronopol, these products are both biocide and surfactant with detergent function, as a disinfectant and preservative cosmetics production and extensive use in medical, although bacteriostatic effect is good, but because these compounds in aqueous solution can be precipitated, easy to change color and prone to bubbles, generally cannot be used as preservative in most of the in vitro diagnostic (IVD) reagent.
The formation of 5-bromo-5-nitro-1,3-dioxane (BND) can not only improve the bacteriostatic ability, but also increase the stability under alkaline conditions, reduce discoloration and no longer release formaldehyde. BND-10 which is 10% propylene glycol solution, easily applied into various kinds of in vitro diagnostic reagent, and can work with NeoCide ® PC series Preservatives like Isothiazolinone. Its features and advantages include but are not limited to:
o Against bacteria, fungi and yeast all have better inhibition effect.
o Broad-spectrum and quickly eliminate the activity of microorganism and biofilm.
o Low concentration, low cost, no interference to the color of the reagent.
o Stable, at the same time worked as surfactant
o Suitable for a wide range of pH, compatibility with enzymes and antibodies
o Environment friendly, biodegradability
Clinical Hematology analysis system in the hospital could be contaminated easily as the reagent pickup systems or pipeline direct contact with blood, in the analysis process, which generated biofilm easily. To use BND-10 as antibacterial agent against streptococcus pneumoniae in diluent and cleaning solution has special effect to extend the shelf life and open shelf life stability. In the IA analysis, BND-10 Preservative as one of first choice applied to most of reagents
NeoCide BND-10 Preservative can replace Sodium Azide (NaN3) which widely applied to in vitro diagnostic reagents. In most cases (alkaline), Sodium Azide has a good antibacterial effect, but Sodium Azide can inhibit the activities of horseradish peroxidase (HRP), superoxide dismutase and other enzymes, so Sodium Azide cannot be added to the secondary antibody containing horseradish peroxidase. At the same time, Sodium Azide has the risks of explosion, very sensitive compounds with heavy metals and the risk of toxicity, inhibit cytochrome oxidase and other enzymes, and can block the formation of oxyhemoglobin in the body, leading to death. Due to the inflammable, explosive and highly toxic nature of Sodium Azide as a dangerous chemical, its procurement, storage, use and other links of the state have special regulatory requirements, its use is increasingly limited. NeoCide BND-10 Preservative can also replace Thimerosal, which was widely applied to in vitro diagnostic reagent, it for both gram positive and negative of strong antibacterial ability, as the broad-spectrum antibacterial agent, because a small amount of organic mercury in theory has the nerve toxicity, so the use of thimerosal security issues by the attention of people.
